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Amylin receptor activation attenuates intoxication effects and decreases chronic alcohol/drug use and relapse

While this positions cagrilintide as slightly less potent in vitro than salmon calcitonin (sCT, pEC ~1112), its superior stability, reduced aggregation risk, and long acting pharmacokinetic profile make it far more practical for sustained receptor engagement in both animal models and clinical investigation

Forms studied: Dihexa has been tested in oral formulations and subcutaneous injections